HOXB6

Identifiers Symbols HOXB6; HOX2; HOX2B; HU-2; Hox-2.2 External IDs OMIM: 142961 MGI: 96187 HomoloGene: 7366 GeneCards: HOXB6 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• transcription, DNA-dependent • regulation of transcription, DNA-dependent • anterior/posterior axis specification, embryo • erythrocyte homeostasis • embryonic skeletal system morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3216 15414 Ensembl ENSG00000108511 ENSMUSG00000000690 UniProt P17509 P09023 RefSeq (mRNA) NM_018952 NM_008269 RefSeq (protein) NP_061825 NP_032295 Location (UCSC) Chr 17:
46.67 – 46.68 Mb Chr 11:
96.29 – 96.3 Mb PubMed search

Homeobox protein Hox-B6 is a protein that in humans is encoded by the HOXB6 gene.

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.