HOXB5

Identifiers Symbols HOXB5; HHO.C10; HOX2; HOX2A; HU-1; Hox2.1 External IDs OMIM: 142960 MGI: 96186 HomoloGene: 37585 GeneCards: HOXB5 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• transcription, DNA-dependent • anatomical structure morphogenesis • anterior/posterior pattern specification • endothelial cell differentiation • embryonic skeletal system morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3215 15413 Ensembl ENSG00000120075 ENSMUSG00000038700 UniProt P09067 P09079 RefSeq (mRNA) NM_002147 NM_008268 RefSeq (protein) NP_002138 NP_032294 Location (UCSC) Chr 17:
46.67 – 46.67 Mb Chr 11:
96.3 – 96.31 Mb PubMed search

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.