HOXA9

Identifiers Symbols HOXA9; ABD-B; HOX1; HOX1.7; HOX1G External IDs OMIM: 142956 MGI: 96180 HomoloGene: 7766 GeneCards: HOXA9 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • protein binding • enzyme binding • sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• transcription, DNA-dependent • multicellular organismal development • endothelial cell activation • negative regulation of myeloid cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3205 15405 Ensembl ENSG00000078399 ENSMUSG00000038227 UniProt P31269 P09631 RefSeq (mRNA) NM_152739 NM_010456 RefSeq (protein) NP_689952 NP_034586 Location (UCSC) Chr 7:
27.2 – 27.21 Mb Chr 6:
52.22 – 52.23 Mb PubMed search

Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.