| Gene Ontology | |
|---|---|
| Molecular function | • sequence-specific DNA binding transcription factor activity • transcription factor binding • sequence-specific DNA binding |
| Cellular component | • nucleus |
| Biological process | • negative regulation of transcription from RNA polymerase II promoter • angiogenesis • negative regulation of cell-matrix adhesion • negative regulation of leukocyte migration • transcription, DNA-dependent • anterior/posterior pattern specification • negative regulation of keratinocyte differentiation • negative regulation of monocyte differentiation • negative regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • embryonic skeletal system morphogenesis • stem cell differentiation |
| Sources: Amigo / QuickGO | |
27.19 – 27.2 Mb
52.21 – 52.22 Mb
Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.