| Gene Ontology | |
|---|---|
| Molecular function | • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding |
| Cellular component | • nucleus |
| Biological process | • respiratory system process • transcription, DNA-dependent • anterior/posterior pattern specification • positive regulation of receptor biosynthetic process • cell migration • negative regulation of angiogenesis • thyroid gland development • regulation of mammary gland epithelial cell proliferation • multicellular organism growth • positive regulation of apoptotic process • positive regulation of myeloid cell differentiation • negative regulation of erythrocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • lung alveolus development • embryonic skeletal system morphogenesis • bronchiole development • epithelial tube branching involved in lung morphogenesis • lung goblet cell differentiation • lung-associated mesenchyme development • trachea cartilage morphogenesis • intestinal epithelial cell maturation • mesenchymal-epithelial cell signaling • mammary gland epithelial cell differentiation • mammary gland alveolus development • cell-cell signaling involved in mammary gland development |
| Sources: Amigo / QuickGO | |
27.18 – 27.18 Mb
52.2 – 52.2 Mb
Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.