Hormone - Physiology of Hormones

Physiology of Hormones

Most cells are capable of producing one or more molecules, which act as signaling molecules to other cells, altering their growth, function, or metabolism. The classical hormones produced by cells in the endocrine glands mentioned so far in this article are cellular products, specialized to serve as regulators at the overall organism level. However, they may also exert their effects solely within the tissue in which they are produced and originally released.

The rate of hormone biosynthesis and secretion is often regulated by a homeostatic negative feedback control mechanism. Such a mechanism depends on factors that influence the metabolism and excretion of hormones. Thus, higher hormone concentration alone cannot trigger the negative feedback mechanism. Negative feedback must be triggered by overproduction of an "effect" of the hormone.

Hormone secretion can be stimulated and inhibited by:

  • Other hormones (stimulating- or releasing -hormones)
  • Plasma concentrations of ions or nutrients, as well as binding globulins
  • Neurons and mental activity
  • Environmental changes, e.g., of light or temperature

One special group of hormones is the tropic hormones that stimulate the hormone production of other endocrine glands. For example, thyroid-stimulating hormone (TSH) causes growth and increased activity of another endocrine gland, the thyroid, which increases output of thyroid hormones.

A recently identified class of hormones is that of the "hunger hormones" - ghrelin, orexin, and PYY 3-36 - and "satiety hormones" - e.g., cholecystokinin, leptin, nesfatin-1, obestatin.

To release active hormones quickly into the circulation, hormone biosynthetic cells may produce and store biologically inactive hormones in the form of pre- or prohormones. These can then be quickly converted into their active hormone form in response to a particular stimulus.

Read more about this topic:  Hormone

Famous quotes containing the words physiology and/or hormones:

    I have more in common with a Mexican man than with a white woman.... This opinion ... chagrins women who sincerely believe our female physiology unequivocally binds all women throughout the world, despite the compounded social prejudices that daily affect us all in different ways. Although women everywhere experience life differently from men everywhere, white women are members of a race that has proclaimed itself globally superior for hundreds of years.
    Ana Castillo (b. 1953)

    Teenage boys, goaded by their surging hormones ... run in packs like the primal horde. They have only a brief season of exhilarating liberty between control by their mothers and control by their wives.
    Camille Paglia (b. 1947)