Homeboy(s) or Homeboyz may refer to:
- Homie or "homeboy", a slang term
In film and television:
- Home Boy, a Philippine TV talk show
- Homeboy (film), a 1988 film starring Mickey Rourke
- Homeboys of Oz, a fictional gang in the TV series Oz
- Sold (TV series), a British television series, produced under the working title Homeboys
In literature:
- Homeboyz, a novel by Alan Lawrence Sitomer
- Home Boy, a novel by H. M. Naqvi
- Homeboy, a novel by Seth Morgan (novelist)
In music:
- "Homeboy" (Eric Church song)
- Homeboys (Adam Again album), an album by band Adam Again
- "Homeboy", a song by Adorable (band)
- "Homeboy", a song by JoJo from JoJo (album)
In sports:
- Home Boy FC, an Honduran football (soccer) club
- Homeboyz RFC, a Kenyan Rugby Union club
In other uses:
- Homeboy Industries, a youth program to assist gang members