HIV Disease Progression Rates - HIV Subtype Variation and Effect On Progression Rates

HIV Subtype Variation and Effect On Progression Rates

The HIV-1 subtype that an individual becomes infected with can be a major factor in the rate of progression from sero-conversion to AIDS. Individuals infected with subtypes C, D and G are 8 times more likely to develop AIDS than individuals infected with subtype A. In Uganda, where subtypes A and D are most prevalent, subtype D is associated with faster disease progression compared with subtype A. Age has also been shown to be a major factor in determining survival and the rate of disease progression, with individuals over 40 years of age at sero-conversion being associated with rapid progression.

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