Histamine H1 Receptor

Histamine H1 Receptor

Identifiers Symbols HRH1; H1-R; hisH1 External IDs OMIM: 600167 MGI: 107619 HomoloGene: 668 IUPHAR: H₁ ChEMBL: 231 GeneCards: HRH1 Gene

Gene Ontology
Molecular function	• G-protein coupled receptor activity • histamine receptor activity • histamine binding
Cellular component	• nucleus • nucleolus • cytoplasm • plasma membrane • integral to plasma membrane
Biological process	• inflammatory response • G-protein coupled receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • synaptic transmission • response to gravity • negative regulation of steroid biosynthetic process • positive regulation of inositol trisphosphate biosynthetic process • positive regulation of nitric oxide biosynthetic process • positive regulation of vasoconstriction • inositol phosphate-mediated signaling • cellular response to histamine
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3269 15465 Ensembl ENSG00000196639 ENSMUSG00000053004 UniProt P35367 P70174 RefSeq (mRNA) NM_000861.3 NM_001252642.1 RefSeq (protein) NP_000852.1 NP_001239571.1 Location (UCSC) Chr 3:
11.18 – 11.31 Mb Chr 6:
114.4 – 114.48 Mb PubMed search

The H₁ receptor is a histamine receptor belonging to the family of Rhodopsin like G-protein-coupled receptors. This receptor, which is activated by the biogenic amine histamine, is expressed throughout the body, to be specific, in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system. The H₁ receptor is linked to an intracellular G-protein (G_q) that activates phospholipase C and the phosphatidylinositol (PIP2) signaling pathway. Antihistamines, which act on this receptor, are used as anti-allergic drugs. The crystal structure of the receptor has been determined (shown on the right).