HINT1

Identifiers Symbols HINT1; HINT; NMAN; PKCI-1; PRKCNH1 External IDs OMIM: 601314 MGI: 1321133 HomoloGene: 3904 ChEMBL: 5878 GeneCards: HINT1 Gene EC number 3.-.-.-

Gene Ontology
Molecular function	• protein kinase C binding • hydrolase activity
Cellular component	• nucleus • cytoplasm • cytoskeleton • plasma membrane
Biological process	• signal transduction
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3094 15254 Ensembl ENSG00000169567 ENSMUSG00000020267 UniProt P49773 P70349 RefSeq (mRNA) NM_005340 NM_008248 RefSeq (protein) NP_005331 NP_032274 Location (UCSC) Chr 5:
130.49 – 130.51 Mb Chr 11:
54.87 – 54.87 Mb PubMed search

Histidine triad nucleotide-binding protein 1 is a protein that in humans is encoded by the HINT1 gene. It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and Microphthalmia-associated transcription factor (MITF) activity in human mast cells. In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.