Heteronuclear Single Quantum Coherence Spectroscopy
The Heteronuclear Single Quantum Coherence (HSQC) or Heteronuclear Single Quantum Correlation experiment is used frequently in NMR spectroscopy of organic molecules and is of particular significance in the field of protein NMR. The experiment was first described by Geoffrey Bodenhausen and D. J. Ruben in 1980. The resulting spectrum is two-dimensional with one axis for 1H and the other for a heteronucleus (an atomic nucleus other than a proton), most often 13C or 15N. The spectrum contains a peak for each unique proton attached to the heteronucleus being considered.
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