Definition
A good, clinically useful H. pylori eradication protocol is a treatment protocol, which ensures at least 80% H. pylori eradication rate, is not longer than 14 days (preferably 7 or 10 days) and is not too toxic (side effects should occur in not more than 10–15% patients receiving treatment by this protocol, and should not be so severe to warrant treatment discontinuation).
The treatment regimen should also be easy to follow by the patient, both human and canine, to improve or maintain high rate of treatment compliance.
During last decades, several new eradication protocols have been developed. This allowed clinicians to target several goals:
- improved treatment compliance;
- sharpened dietary component;
- no need to strictly follow a diet, due to new proton pump inhibitor efficacy;
- decreased duration of therapy: from 14 to 7–10 days;
- decreased number of different tablets to ingest, due to combined standard preparations;
- decreased number of daily tablets from 4 times a day to twice-daily schemes;
- lessened toxicity and probability of side effects;
- improved clinical efficacy in terms of H. pylori eradication ratios;
- overcoming the problem of antibiotic resistance;
- satisfied the need for alternative protocols for those patients who are allergic to one of the standard antibiotics used in standard protocols.
Read more about this topic: Helicobacter Pylori Eradication Protocols
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