HDAC7

HDAC7

Identifiers Symbols HDAC7; HD7A; HDAC7A External IDs OMIM: 606542 MGI: 1891835 HomoloGene: 9124 ChEMBL: 2716 GeneCards: HDAC7 Gene EC number 3.5.1.98

Gene Ontology
Molecular function	• chromatin binding • transcription corepressor activity • protein kinase C binding • protein kinase binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • activating transcription factor binding • metal ion binding • NAD-dependent histone deacetylase activity (H3-K9 specific) • NAD-dependent histone deacetylase activity (H4-K16 specific) • repressing transcription factor binding • 14-3-3 protein binding • NAD-dependent histone deacetylase activity (H3-K18 specific)
Cellular component	• histone deacetylase complex • nucleus • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • vasculogenesis • transcription, DNA-dependent • cell-cell junction assembly • Notch signaling pathway • negative regulation of interleukin-2 production • negative regulation of osteoblast differentiation • positive regulation of cell migration involved in sprouting angiogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 51564 56233 Ensembl ENSG00000061273 ENSMUSG00000022475 UniProt Q8WUI4 Q8C2B3 RefSeq (mRNA) NM_001098416 NM_001204275 RefSeq (protein) NP_001091886 NP_001191204 Location (UCSC) Chr 12:
48.18 – 48.23 Mb Chr 15:
97.79 – 97.84 Mb PubMed search

Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via transcriptional corepressor SMRT. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.