Hdac7

HDAC7

Identifiers Symbols HDAC7; HD7A; HDAC7A External IDs OMIM: 606542 MGI: 1891835 HomoloGene: 9124 ChEMBL: 2716 GeneCards: HDAC7 Gene EC number 3.5.1.98

Gene Ontology
Molecular function	• chromatin binding • transcription corepressor activity • protein kinase C binding • protein kinase binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • activating transcription factor binding • metal ion binding • NAD-dependent histone deacetylase activity (H3-K9 specific) • NAD-dependent histone deacetylase activity (H4-K16 specific) • repressing transcription factor binding • 14-3-3 protein binding • NAD-dependent histone deacetylase activity (H3-K18 specific)
Cellular component	• histone deacetylase complex • nucleus • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • vasculogenesis • transcription, DNA-dependent • cell-cell junction assembly • Notch signaling pathway • negative regulation of interleukin-2 production • negative regulation of osteoblast differentiation • positive regulation of cell migration involved in sprouting angiogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 51564 56233 Ensembl ENSG00000061273 ENSMUSG00000022475 UniProt Q8WUI4 Q8C2B3 RefSeq (mRNA) NM_001098416 NM_001204275 RefSeq (protein) NP_001091886 NP_001191204 Location (UCSC) Chr 12:
48.18 – 48.23 Mb Chr 15:
97.79 – 97.84 Mb PubMed search

Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.