HDAC4

HDAC4

Identifiers Symbols HDAC4; AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDACA External IDs OMIM: 605314 MGI: 3036234 HomoloGene: 55946 ChEMBL: 3524 GeneCards: HDAC4 Gene EC number 3.5.1.98

Gene Ontology
Molecular function	• transcription corepressor activity • histone deacetylase activity • protein binding • transcription factor binding • zinc ion binding • protein kinase binding • potassium ion binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • protein deacetylase activity • activating transcription factor binding • histone deacetylase binding • sequence-specific DNA binding • transcription regulatory region DNA binding • NAD-dependent histone deacetylase activity (H3-K9 specific) • NAD-dependent histone deacetylase activity (H4-K16 specific) • repressing transcription factor binding • NAD-dependent histone deacetylase activity (H3-K18 specific)
Cellular component	• histone deacetylase complex • nucleus • cytoplasm • cytosol • transcriptional repressor complex • neuromuscular junction • actomyosin
Biological process	• negative regulation of transcription from RNA polymerase II promoter • skeletal system development • osteoblast development • chromatin remodeling • transcription, DNA-dependent • inflammatory response • nervous system development • positive regulation of cell proliferation • negative regulation of cell proliferation • negative regulation of myotube differentiation • regulation of cardiac muscle contraction by calcium ion signaling • response to denervation involved in regulation of muscle adaptation • cardiac muscle hypertrophy in response to stress • histone deacetylation • B cell differentiation • positive regulation of protein sumoylation • peptidyl-lysine deacetylation • B cell activation • regulation of protein binding • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of osteoblast differentiation • negative regulation of glycolysis • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • response to interleukin-1 • histone H3 deacetylation • histone H4 deacetylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9759 208727 Ensembl ENSG00000068024 ENSMUSG00000026313 UniProt P56524 Q6NZM9 RefSeq (mRNA) NM_006037 NM_207225 RefSeq (protein) NP_006028 NP_997108 Location (UCSC) Chr 2:
239.97 – 240.32 Mb Chr 1:
91.93 – 92.15 Mb PubMed search

Histone deacetylase 4, also known as HDAC4, is a protein which in humans is encoded by the HDAC4 gene.