HDAC3

HDAC3

Identifiers Symbols HDAC3; HD3; RPD3; RPD3-2 External IDs OMIM: 605166 MGI: 1343091 HomoloGene: 48250 ChEMBL: 1829 GeneCards: HDAC3 Gene EC number 3.5.1.98

Gene Ontology
Molecular function	• transcription corepressor activity • histone deacetylase activity • protein binding • transcription factor binding • enzyme binding • chromatin DNA binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • protein deacetylase activity • histone deacetylase binding • NAD-dependent histone deacetylase activity (H3-K9 specific) • NAD-dependent histone deacetylase activity (H4-K16 specific) • NAD-dependent histone deacetylase activity (H3-K18 specific)
Cellular component	• histone deacetylase complex • chromatin • nucleus • nucleoplasm • cytoplasm • spindle microtubule • transcriptional repressor complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-dependent • protein deacetylation • Notch signaling pathway • regulation of mitotic cell cycle • negative regulation of myotube differentiation • chromatin modification • circadian regulation of gene expression • regulation of multicellular organism growth • response to drug • negative regulation of apoptotic process • cellular lipid metabolic process • small molecule metabolic process • negative regulation of cell cycle • negative regulation of transcription, DNA-dependent • negative regulation of JNK cascade • nerve growth factor receptor signaling pathway • spindle assembly
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8841 15183 Ensembl ENSG00000171720 ENSMUSG00000024454 UniProt O15379 O88895 RefSeq (mRNA) NM_003883 NM_010411 RefSeq (protein) NP_003874 NP_034541 Location (UCSC) Chr 5:
141 – 141.02 Mb Chr 18:
37.94 – 37.95 Mb PubMed search

Histone deacetylase 3 is an enzyme that in humans is encoded by the HDAC3 gene.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.