HDAC1

HDAC1

Identifiers Symbols HDAC1; GON-10; HD1; RPD3; RPD3L1 External IDs OMIM: 601241 MGI: 108086 HomoloGene: 68426 ChEMBL: 325 GeneCards: HDAC1 Gene EC number 3.5.1.98

Gene Ontology
Molecular function	• core promoter binding • RNA polymerase II repressing transcription factor binding • RNA polymerase II transcription corepressor activity • sequence-specific DNA binding transcription factor activity • histone deacetylase activity • protein binding • transcription factor binding • enzyme binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • protein deacetylase activity • activating transcription factor binding • histone deacetylase binding • NAD-dependent histone deacetylase activity (H3-K9 specific) • NAD-dependent histone deacetylase activity (H4-K16 specific) • NAD-dependent histone deacetylase activity (H3-K18 specific)
Cellular component	• histone deacetylase complex • nuclear chromatin • nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • Sin3 complex • NuRD complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • mitotic cell cycle • chromatin remodeling • transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • protein deacetylation • transforming growth factor beta receptor signaling pathway • Notch signaling pathway • blood coagulation • positive regulation of cell proliferation • epidermal cell differentiation • gene expression • negative regulation of myotube differentiation • positive regulation of receptor biosynthetic process • chromatin modification • histone deacetylation • virus-host interaction • odontogenesis of dentin-containing tooth • embryonic digit morphogenesis • negative regulation of apoptotic process • negative regulation by host of viral transcription • negative regulation of cell cycle • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • nerve growth factor receptor signaling pathway • negative regulation of androgen receptor signaling pathway • hair follicle placode formation • eyelid development in camera-type eye • fungiform papilla formation • histone H3 deacetylation • histone H4 deacetylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3065 433759 Ensembl ENSG00000116478 ENSMUSG00000028800 UniProt Q13547 O09106 RefSeq (mRNA) NM_004964.2 NM_008228.2 RefSeq (protein) NP_004955.2 NP_032254.1 Location (UCSC) Chr 1:
32.76 – 32.8 Mb Chr 4:
129.52 – 129.54 Mb PubMed search

Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.