GUCY1A3

Identifiers Symbols GUCY1A3; GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1 External IDs OMIM: 139396 MGI: 1926562 HomoloGene: 37360 ChEMBL: 3796 GeneCards: GUCY1A3 Gene EC number 4.6.1.2

Gene Ontology
Molecular function	• guanylate cyclase activity • receptor activity • GTP binding • heme binding • protein heterodimerization activity
Cellular component	• guanylate cyclase complex, soluble
Biological process	• nitric oxide mediated signal transduction • blood coagulation • blood circulation • regulation of blood pressure • response to herbicide • response to organic cyclic compound • positive regulation of cGMP biosynthetic process • response to defense-related host nitric oxide production • relaxation of vascular smooth muscle
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2982 60596 Ensembl ENSG00000164116 ENSMUSG00000033910 UniProt Q02108 Q9ERL9 RefSeq (mRNA) NM_000856 NM_021896 RefSeq (protein) NP_000847 NP_068696 Location (UCSC) Chr 4:
156.59 – 156.65 Mb Chr 3:
82.09 – 82.15 Mb PubMed search

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998).