Computing
- Generalised suffix tree, a tree-like data structure
- GeSbTe, a phase-change material used for rewritable optical discs and phase-change memory
- GNOME System Tools, part of the GNOME desktop environment
- GNU Smalltalk, an implementation of the Smalltalk language
- GST Computer Systems, a group of companies based in Cambridge, England
- GStreamer, a multimedia framework
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