GSK3A
| Gene Ontology | |
|---|---|
| Molecular function | • protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase A catalytic subunit binding • tau-protein kinase activity |
| Cellular component | • cytosol • beta-catenin destruction complex |
| Biological process | • regulation of systemic arterial blood pressure • cardiac left ventricle morphogenesis • glycogen metabolic process • regulation of gene expression by genetic imprinting • protein phosphorylation • activation of signaling protein activity involved in unfolded protein response • epidermal growth factor receptor signaling pathway • nervous system development • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • positive regulation of peptidyl-threonine phosphorylation • negative regulation of UDP-glucose catabolic process • Wnt receptor signaling pathway • cell migration • positive regulation of cAMP biosynthetic process • endoplasmic reticulum unfolded protein response • negative regulation of TOR signaling cascade • cellular response to insulin stimulus • positive regulation of peptidyl-serine phosphorylation • hypermethylation of CpG island • negative regulation of glycogen biosynthetic process • positive regulation of protein catabolic process • positive regulation of heart contraction • positive regulation of transcription from RNA polymerase II promoter • negative regulation of glucose import • negative regulation of insulin receptor signaling pathway • nerve growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • negative regulation of transferase activity • negative regulation of cell growth involved in cardiac muscle cell development • cellular response to lithium ion • cellular response to organic cyclic compound • positive regulation of adrenergic receptor signaling pathway • negative regulation of canonical Wnt receptor signaling pathway • negative regulation of type B pancreatic cell development • negative regulation of glycogen (starch) synthase activity • positive regulation of glycogen (starch) synthase activity |
| Sources: Amigo / QuickGO | |
42.73 – 42.75 Mb
25.23 – 25.24 Mb
Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.
Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.
Read more about GSK3A: Model Organisms