Gold Standard Ambiguity
Sometimes "Gold Standard test" refers to the best performing test available. In these cases, there is no other criterion against which it can be compared and it is equivalent to a definition. When referring to this meaning, gold standard tests are normally not performed at all. This is because the "gold standard" test may be difficult to perform or may be impossible to perform on a living person (i.e. the test is performed as part of an autopsy or may take too long for the results of the test to be available to be clinically useful).
Other times, "Gold standard" does not refer to the best performing test available, but the best available under reasonable conditions. For example, in this sense, a MRI is the gold standard for brain tumour diagnosis, though it is not as good as a biopsy. In this case the sensitivity and specifity of the gold standard are not 100% and it is said to be an "imperfect gold standard" or "Alloyed gold standard"
Read more about this topic: Gold Standard (test)
Famous quotes containing the words gold, standard and/or ambiguity:
“1st Murderer. Where’s thy conscience now?...
2nd Murderer. I’ll not meddle with it. It makes a man a coward.... It fills a man full of obstacles. It made me once restore a purse of gold that by chance I found. It beggars any man that keeps it. It is turned out of towns and cities for a dangerous thing, and every man that means to live well endeavors to trust to himself and live without it.”
—William Shakespeare (1564–1616)
“A dwarf who brings a standard along with him to measure his own size—take my word, is a dwarf in more articles than one.”
—Laurence Sterne (1713–1768)
“Legends of prediction are common throughout the whole Household of Man. Gods speak, spirits speak, computers speak. Oracular ambiguity or statistical probability provides loopholes, and discrepancies are expunged by Faith.”
—Ursula K. Le Guin (b. 1929)