Gold Standard Ambiguity
Sometimes "Gold Standard test" refers to the best performing test available. In these cases, there is no other criterion against which it can be compared and it is equivalent to a definition. When referring to this meaning, gold standard tests are normally not performed at all. This is because the "gold standard" test may be difficult to perform or may be impossible to perform on a living person (i.e. the test is performed as part of an autopsy or may take too long for the results of the test to be available to be clinically useful).
Other times, "Gold standard" does not refer to the best performing test available, but the best available under reasonable conditions. For example, in this sense, a MRI is the gold standard for brain tumour diagnosis, though it is not as good as a biopsy. In this case the sensitivity and specifity of the gold standard are not 100% and it is said to be an "imperfect gold standard" or "Alloyed gold standard"
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Famous quotes containing the words gold, standard and/or ambiguity:
“Daughter to that good Earl, once President
Of England’s Council and her Treasury,
Who lived in both, unstain’d with gold or fee,
And left them both, more in himself content.
Till the sad breaking of that Parliament
Broke him, as that dishonest victory
At Chaeronea, fatal to liberty,
Kill’d with report that old man eloquent;—”
—John Milton (1608–1674)
“The art of advertisement, after the American manner, has introduced into all our life such a lavish use of superlatives, that no standard of value whatever is intact.”
—Wyndham Lewis (1882–1957)
“Indeed, it is that ambiguity and ambivalence which often is so puzzling in women—the quality of shifting from child to woman, the seeming helplessness one moment and the utter self-reliance the next that baffle us, that seem most difficult to understand. These are the qualities that make her a mystery, the qualities that provoked Freud to complain, “What does a woman want?””
—Lillian Breslow Rubin (20th century)