Gold Standard Ambiguity
Sometimes "Gold Standard test" refers to the best performing test available. In these cases, there is no other criterion against which it can be compared and it is equivalent to a definition. When referring to this meaning, gold standard tests are normally not performed at all. This is because the "gold standard" test may be difficult to perform or may be impossible to perform on a living person (i.e. the test is performed as part of an autopsy or may take too long for the results of the test to be available to be clinically useful).
Other times, "Gold standard" does not refer to the best performing test available, but the best available under reasonable conditions. For example, in this sense, a MRI is the gold standard for brain tumour diagnosis, though it is not as good as a biopsy. In this case the sensitivity and specifity of the gold standard are not 100% and it is said to be an "imperfect gold standard" or "Alloyed gold standard"
Read more about this topic: Gold Standard (test)
Famous quotes containing the words gold, standard and/or ambiguity:
“In the gold mouth of a flower
the black smell of spring earth.
No more skulls on our desks
but the pervasive
testing of death....”
—Denise Levertov (b. 1923)
“An indirect quotation we can usually expect to rate only as better or worse, more or less faithful, and we cannot even hope for a strict standard of more and less; what is involved is evaluation, relative to special purposes, of an essentially dramatic act.”
—Willard Van Orman Quine (b. 1908)
“Indeed, it is that ambiguity and ambivalence which often is so puzzling in women—the quality of shifting from child to woman, the seeming helplessness one moment and the utter self-reliance the next that baffle us, that seem most difficult to understand. These are the qualities that make her a mystery, the qualities that provoked Freud to complain, “What does a woman want?””
—Lillian Breslow Rubin (20th century)