GNB1

Identifiers Symbol GNB1 External IDs OMIM: 139380 MGI: 95781 HomoloGene: 55532 GeneCards: GNB1 Gene

Gene Ontology
Molecular function	• GTPase activity • signal transducer activity • type 1 angiotensin receptor binding • GTPase binding
Cellular component	• photoreceptor outer segment • intracellular • heterotrimeric G-protein complex • plasma membrane • membrane
Biological process	• energy reserve metabolic process • GTP catabolic process • signal transduction • adenylate cyclase-activating dopamine receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • elevation of cytosolic calcium ion concentration • G-protein coupled acetylcholine receptor signaling pathway • Ras protein signal transduction • synaptic transmission • blood coagulation • cell proliferation • platelet activation • small molecule metabolic process • sensory perception of taste • retina development in camera-type eye • cellular response to glucagon stimulus • cellular response to prostaglandin E stimulus • cellular response to catecholamine stimulus
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2782 14688 Ensembl ENSG00000078369 ENSMUSG00000029064 UniProt P62873 P62874 RefSeq (mRNA) NM_002074 NM_001160016 RefSeq (protein) NP_002065 NP_001153488 Location (UCSC) Chr 1:
1.72 – 1.82 Mb Chr 4:
155.49 – 155.56 Mb PubMed search

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.