Glycine Dehydrogenase (decarboxylating) - Reaction

Reaction

Glycine dehydrogenase (decarboxylating) (EC 1.4.4.2) is an enzyme that catalyzes the following chemical reaction:

glycine + H-protein-lipoyllysine H-protein-S-aminomethyldihydrolipoyllysine + CO2

Thus, the two substrates of this enzyme are glycine and H-protein-lipoyllysine, whereas its two products are H-protein-S-aminomethyldihydrolipoyllysine and CO2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with a disulfide as acceptor. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.

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