Glycine Cleavage System - Components

Components

Name EC number Function
T-protein (GCST or AMT) EC 2.1.2.10 aminomethyltransferase
P-protein (GLDC) EC 1.4.4.2 glycine dehydrogenase (decarboxylating) or just glycine dehydrogenase.
L-protein (GCSL or DLD) EC 1.8.1.4 known by many names, but most commonly dihydrolipoyl dehydrogenase
H-protein (GCSH) is modified with lipoic acid and interacts with all other components in a cycle of reductive methylamination (catalysed by the P-protein), methylamine transfer (catalysed by the T-protein) and electron transfer (catalysed by the L-protein).

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