Gluten Sensitivity - Comparative Pathophysiology

Comparative Pathophysiology

Comparison of different forms of gluten sensitivity
Gluten-sensitive enteropathy Wheat allergy Gluten-sensitive idiopathic neuropathy
Typical symptoms steatorrhoea, malnutrition, diarrhea, lactose intolerance, food allergies eczema, asthma ataxia, peripheral neuropathies
Primary tissue targets epithelia of small intestine (epi) dermis, bronchi, intestines CNS, Peripheral nerves
Atypical pathologies other autoimmune diseases, chronic constipation, neuropathies, cancer (lymphoid) arthritis, migraines, anaphylaxis (exercise or aspirin induced) unknown
Secondary targets (common) blood (chemistry), bowel, nervous system, autoantigens connective tissue, CNS, vascular
Immunoglobin isotype IgA, IgG IgE, IgG,
Antibody recognition α/β,γ-gliadin (AGA), transglutaminase (ATA) albumins, globulins, prolamins (ω-gliadin)(AGA), glutelins (LMW)(AGA) α/β-gliadin
HLA associations DQ2.5, DQ8, DQ2.2/DQ7.5 unknown DQ2, DQ8?, DQ1?
Cellular immunity T-cells, Eosinophils, Monocytes Mast cells, Eosinophils unknown
Innate responses (α-gliadin) immune, increased permeability (ω-5 gliadin)- increased permeability unknown
Background & references Celiac disease, GSEA conditions Wheat allergy IGS Neuropathies

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