Comparative Pathophysiology
| Gluten-sensitive enteropathy | Wheat allergy | Gluten-sensitive idiopathic neuropathy | |
|---|---|---|---|
| Typical symptoms | steatorrhoea, malnutrition, diarrhea, lactose intolerance, food allergies | eczema, asthma | ataxia, peripheral neuropathies |
| Primary tissue targets | epithelia of small intestine | (epi) dermis, bronchi, intestines | CNS, Peripheral nerves |
| Atypical pathologies | other autoimmune diseases, chronic constipation, neuropathies, cancer (lymphoid) | arthritis, migraines, anaphylaxis (exercise or aspirin induced) | unknown |
| Secondary targets (common) | blood (chemistry), bowel, nervous system, autoantigens | connective tissue, CNS, vascular | |
| Immunoglobin isotype | IgA, IgG | IgE, | IgG, |
| Antibody recognition | α/β,γ-gliadin (AGA), transglutaminase (ATA) | albumins, globulins, prolamins (ω-gliadin)(AGA), glutelins (LMW)(AGA) | α/β-gliadin |
| HLA associations | DQ2.5, DQ8, DQ2.2/DQ7.5 | unknown | DQ2, DQ8?, DQ1? |
| Cellular immunity | T-cells, Eosinophils, Monocytes | Mast cells, Eosinophils | unknown |
| Innate responses | (α-gliadin) immune, increased permeability | (ω-5 gliadin)- increased permeability | unknown |
| Background & references | Celiac disease, GSEA conditions | Wheat allergy | IGS Neuropathies |
Read more about this topic: Gluten Sensitivity
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