Glucuronidation - Affected Drugs

Affected Drugs

Many drugs which are substrates for glucuronidation as part of their metabolism are significantly affected by inhibitors or inducers of their specific glucuronisyltransferase types:

Substrate Inhibitors of glucuronidation Inducers of glucuronidation,
Morphine
  • Amitriptyline
  • Clomipramine
  • Clonazepam
  • Diazepam
  • Flurnitrazepam
  • Lorazepam
  • Nitrazepam
  • Oxazepam
  • Codeine
  • Rifampin
  • Tobacco smoking
  • Phenobarbital
Oxazepam
  • Ethinylestradiol
  • Fenoprofen
  • Ibuprofen
  • Ketoprofen
  • Naproxen
  • Phenobarbitone
  • Phenytoin
Bilirubin
  • Phenobarbital
Acetaminophen
  • Ethinylestradiol
  • Probenecid
  • Propranolol
Androsterone
  • Promethazine
  • Chlorpromazine
Carbamazepine-
10,1 1-transdiol
  • Valproic acid
Codeine
  • Amitriptyline
  • Diclofenac
Lamotrigine
  • Sertraline
  • Valproic acid
Lorazepam
  • Ethinylestradiol
  • Probenecid
  • Valproic acid
Temazepam
  • Probenecid
Testosterone
  • Amitriptyline
  • Chlorpromazine
  • Imipramine
  • Promethazine
Zidovudine
  • Probenecid
  • Valproic acid

Read more about this topic:  Glucuronidation

Famous quotes containing the words affected and/or drugs:

    The great war that broke so suddenly upon the world two years ago, and which has swept up within its flame so great a part of the civilized world, has affected us very profoundly.... With its causes and its objects we are not concerned. The obscure fountains from which its stupendous flood has burst we are not interested to search for or explore.
    Woodrow Wilson (1856–1924)

    There is not much sense in suffering, since drugs can be given for pain, itching, and other discomforts. The belief has long died that suffering here on earth will be rewarded in heaven. Suffering has lost its meaning.
    Elisabeth Kübler-Ross (b. 1926)