Notable People
- Landgravine Elisabeth Amalie of Hesse-Darmstadt (1635–1709), Electress Palatine, ancestress of most of today's royals
- Johann Georg Rosenmüller (1736–1815), professor of theology at the university
- Justus von Liebig (1803–1873), chemist, professor. The official name of the University of Giessen is now Justus Liebig University
- Samuel Adler (1809–1891), a noted rabbi in the United States, attended the University of Giessen
- Georg Büchner (1813–1837) studied two years at the University of Gießen
- Peter Düttmann (1923-2001) Luftwaffe Ace
- Wilhelm Liebknecht (1826–1900), founder of the Social Democratic Party of Germany, was born on March 29, 1826 in Giessen
- Adolph Hansen (1851–1920), botanist and professor at University of Giessen
- Wilhelm Conrad Röntgen (1845–1923), physicist, professor of physics from 1879 until 1888 at the University of Giessen. He was buried at the "Alte Friedhof", where his tomb can still be found
- Alfred Milner (1854–1925), British statesman
- Wilhelm Sievers (1860–1921), geographer, explorer, professor at the university
- Marie Wittich (1868–1931), opera singer
- Sigmund Livingston (1872–1946), American lawyer, founder and first president of the Anti-Defamation League
- Ernst Friedberger (1875-1932), immunologist
- Friedrich Kellner (1885–1970), Chief Regional Auditor in Giessen 1948-1950, and Chief Justice Inspector of Laubach, where he wrote his secret WWII diary. The Holocaust Research Unit of Justus Liebig University of Giessen has established the Kellner Project
- Fritz Heichelheim (1901–1968), economist
- James J. O'Donnell (b. 1950), American scholar and University administrator, born in Giessen
- Stefan Bellof (1957–1985), Formula One and Sportscar driver, who died during a race held in Spa-Francorchamps
- Chris Liebing (b. 1968) techno/electronic music producer and DJ
- Demis Nikolaidis (b. 1973), Greek footballer
- Wangari Maathai, Nobel Laureate 2004
- Juli, rock band
- Jonathan Koch (b. 1985), rower
- de:Willy Zschietzschmann (b. 1900), Classical archeologist and author
- Annika Beck (b. 1994), professional tennis player
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