Gabriele Perthes (born January 20, 1948) is a German swimmer. Born in Dessau, Soviet Occupied Zone, she competed in the 1968 Summer Olympics for East Germany.
In 1968, Gabriele Perthes competed in the women's 4×100 m freestyle relay, along with swimmer Uta Schmuck, Roswitha Krause, and Gabriele Wetzko. The team won a silver medal.