Frances Seymour may refer to:
- Frances Howard, Duchess of Richmond (1578–1639), wife of Edward Seymour, 1st Earl of Hertford
- Frances Seymour, Duchess of Somerset (1599–1674), wife of William Seymour, 2nd Duke of Somerset
- Frances Seymour, Lady Hungerford (bef. 1654–1716), daughter of Charles Seymour, 2nd Baron Seymour of Trowbridge
- Frances Seymour, Duchess of Somerset (1699–1754), wife of Algernon Seymour, 7th Duke of Somerset
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