Diseases
Rare primary FDC-tumors have been described. These sarcomas often involve lymphoid tissues, but in a number of cases the tumor has been found in the liver, bile duct, pancreas, thyroid, nasopharynx, palatum, submucosa of the stomach or the duodenum. In a number of chronic inflammatory conditions, cells producing CXCL13 chemokine and carrying such FDCs markers as VCAM-1 and CD21, have been observed at quite unexpected sites, including synovial tissue of patients with rheumatoid arthritis (RA), salivary glands of patients with Sjögren’s syndrome, and the skin of patients with pseudo B cells lymphoma. Follicular dendritic cells participate in HIV-1 infection development both, by providing a haven for HIV-1 and by stimulating HIV-1 replication in adjacent infected monocytic cells via a juxtacrine signaling mechanism. There are also some evidences, that FDCs may promote prion replication and neuroinvasion in neuroinvasive scrapie.
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