Development
Follicular DCs develop from putative mesenchymal precursors. Severe combined immunodeficiency (SCID) mice models demonstrate that these precursors may be transmitted to recipients with bone marrow allotransplants, in which case both donors' and recipients' FDCs networks may later be found in recipients' lymphoid compartments. Interaction between FDCs precursors and lymphoid cells mediated by TNF-a and lymphotoxin (LT) is crucial for normal FDCs development and maintenance. TNF-a binds on the TNF-RI receptor, while LT interacts with LTĪ²-receptor expressed on FDC-precursor. In mice lacking B cells, or with blocked TNF-a and lymphotoxin (LT) production, cells with FDC-phenotype are missing.
Read more about this topic: Follicular Dendritic Cells
Famous quotes containing the word development:
“Men are only as good as their technical development allows them to be.”
—George Orwell (1903–1950)
“For decades child development experts have erroneously directed parents to sing with one voice, a unison chorus of values, politics, disciplinary and loving styles. But duets have greater harmonic possibilities and are more interesting to listen to, so long as cacophony or dissonance remains at acceptable levels.”
—Kyle D. Pruett (20th century)
“This was the Eastham famous of late years for its camp- meetings, held in a grove near by, to which thousands flock from all parts of the Bay. We conjectured that the reason for the perhaps unusual, if not unhealthful development of the religious sentiment here, was the fact that a large portion of the population are women whose husbands and sons are either abroad on the sea, or else drowned, and there is nobody but they and the ministers left behind.”
—Henry David Thoreau (1817–1862)