Contraindications and Cautions
- All patients receiving flucytosine should be under strict medical supervision.
- Hematological, renal and liver function studies should be done frequently during therapy (initially daily, twice a week for the rest of treatment).
- Patients with preexisting bone marrow depression and liver impairment should be treated with caution.
- Concomitant treatment with brivudine is an absolute contraindication.
- Patients treated with drugs compromising bone marrow function (e.g. cytostatics) should be treated carefully. Blood cell counts should be taken very frequently.
- Patients with renal disease should receive flucytosine cautiously and in reduced doses. Guidelines for proper dosing exist. Serum level determinations are mandatory in these patients.
- Hypersensitivity to flucytosine is an absolute contraindication.
Read more about this topic: Flucytosine