FLASH MRI - Physical Basis

Physical Basis

The physical basis of MRI is the spatial encoding of the nuclear magnetic resonance (NMR) signal obtainable from water protons (i.e. hydrogen nuclei) in biologic tissue. In terms of MRI, signals with different spatial encodings that are required for the reconstruction of a full image need to be acquired by generating multiple signals - usually in a repetitive way using multiple radio-frequency excitations.

The generic FLASH technique emerges as a gradient echo sequence which combines a low-flip angle radio-frequency excitation of the NMR signal (recorded as a spatially encoded gradient echo) with a rapid repetition of the basic sequence. The repetition time is usually much shorter than the typical T1 relaxation time of the protons in biologic tissue. Only the combination of (i) a low-flip angle excitation which leaves unused longitudinal magnetization for an immediate next excitation with (ii) the acquisition of a gradient echo which does not need a further radio-frequency pulse that would affect the residual longitudinal magnetization, allows for the rapid repetition of the basic sequence interval and the resulting speed of the entire image acquisition. In fact, the FLASH sequence eliminated all waiting periods previously included to accommodate effects from T1 saturation. FLASH reduced the typical sequence interval to what is minimally required for imaging: a slice-selective radio-frequency pulse and gradient, a phase-encoding gradient, and a (reversed) frequency-encoding gradient generating the echo for data acquisition.

For radial data sampling, the phase- and frequency-encoding gradients are replaced by two simultaneously applied frequency-encoding gradients that rotate the Fourier lines in data space. In either case, repetition times are as short as 2 to 10 milliseconds, so that the use of 64 to 256 repetitions results in image acquisition times of about 0.1 to 2.5 seconds for a two-dimensional image. Most recently, highly undersampled radial FLASH MRI acquisitions have been combined with an iterative image reconstruction by regularized nonlinear inversion to achieve real-time MRI at a temporal resolution of 20 to 30 milliseconds for images with a spatial resolution of 1.5 to 2.0 millimeters. This method allows for a visualization of the beating heart in real time - without synchronization to the electrocardiogram and during free breathing.