In enzymology, a ferric-chelate reductase (EC 1.16.1.7) is an enzyme that catalyzes the chemical reaction
- 2 Fe(II) + NAD+ 2 Fe(III) + NADH + H+
Thus, the two substrates of this enzyme are Fe(II) and NAD+, whereas its 3 products are Fe(III), NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is Fe(II):NAD+ oxidoreductase. Other names in common use include ferric chelate reductase, iron chelate reductase, NADH:Fe3+-EDTA reductase, and NADH2:Fe3+ oxidoreductase.