Structure
Plant-type ferredoxin: NADP+ reductase has two structural domains. The first domain is an antiparallel beta barrel at the amino terminus of the protein that contains the binding domain for the FAD cofactor. The second domain is at the carboxyl terminus of the protein and contains an alpha helix-beta strand fold. This terminal domain is where the NADP+ binds. The active site for the enzyme occurs at the interface between the two domains.
Binding of the enzyme to the thylakoid membrane involves a polyproline type II helix created between two FNR monomers and several proline rich integral membrane proteins.
As of late 2007, 54 structures had been solved for this class of enzymes, with PDB accession codes 1B2R, 1BJK, 1BQE, 1BX0, 1BX1, 1CJC, 1E1L, 1E62, 1E63, 1E64, 1E6E, 1EWY, 1FDR, 1FNB, 1FNC, 1FND, 1FRN, 1FRQ, 1GAQ, 1GAW, 1GJR, 1GO2, 1GR1, 1H42, 1H85, 1JB9, 1OGI, 1OGJ, 1QFY, 1QFZ, 1QG0, 1QGA, 1QGY, 1QGZ, 1QH0, 1QUE, 1QUF, 1SM4, 1W34, 1W35, 1W87, 2B5O, 2BGI, 2BGJ, 2BMW, 2BSA, 2C7G, 2GQW, 2GR0, 2GR1, 2GR2, 2GR3, 2OK7, and 2OK8.
Read more about this topic: Ferredoxin-NADP+ Reductase
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