Fatty-acid Synthase

In enzymology, a fatty-acid synthase (EC 2.3.1.85) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ a long-chain fatty acid + (n+1) CoA + n CO₂ + 2n NADP+

The 4 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, and H+, whereas its 4 products are long-chain fatty acid, CoA, CO₂, and NADP+.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing). This enzyme is also called yeast fatty acid synthase. This enzyme participates in fatty acid biosynthesis and insulin signaling pathway.