Functions of The Calcium-sensing Receptor
- Parathyroid gland: mediates negative feedback mechanisms relating to PTH secretion (PTH secretion should decrease if there is a high blood calcium level). Abnormalities in the CASR here cause hypercalcaemia.
- Kidneys: mediates negative feedback mechanisms relating to calcium reabsorption from the tubular system (reabsorption should decrease if there is a high blood calcium level). Abnormalities in the CASR here cause both hypercalcaemia and hypocalciuria.
Read more about this topic: Familial Hypocalciuric Hypercalcemia
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