EXOC7

EXOC7

Identifiers Symbols EXOC7; 2-5-3p; EX070; EXO70; EXOC1; Exo70p; YJL085W External IDs OMIM: 608163 MGI: 1859270 HomoloGene: 41019 GeneCards: EXOC7 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• exocyst • microtubule organizing center • cytosol • plasma membrane • growth cone membrane • centriolar satellite
Biological process	• exocytosis • protein transport
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23265 53413 Ensembl ENSG00000182473 ENSMUSG00000020792 UniProt Q9UPT5 O35250 RefSeq (mRNA) NM_001013839 NM_001162872 RefSeq (protein) NP_001013861 NP_001156344 Location (UCSC) Chr 17:
74.08 – 74.12 Mb Chr 11:
116.29 – 116.31 Mb PubMed search

Exo70 exocyst complex subunit

crystal structure of the s. cerevisiae exocyst component exo70p

Identifiers

Symbol

Exo70

Pfam

PF03081

Pfam clan

CL0295

InterPro

IPR004140

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70.

It forms one subunit of the exocyst complex. First discovered in Saccharomyces cerevisiae, this and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast. It interacts with the Rho3 GTPase. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud). In humans, the functions of this protein and the exocyst complex are less well characterised: this protein is expressed in several tissues and is thought to also be involved in exocytosis.