Eukaryotic Release Factors

Eukaryotic Release Factors

Identifiers Symbols ETF1; D5S1995; ERF; ERF1; RF1; SUP45L1; TB3-1 External IDs OMIM: 600285 MGI: 2385071 HomoloGene: 3475 GeneCards: ETF1 Gene

Gene Ontology
Molecular function • RNA binding
• translation release factor activity
• protein binding
• translation termination factor activity
• translation release factor activity, codon specific
• ribosome binding
Cellular component • cytoplasm
• cytosol
Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
• translation
• translational termination
• regulation of translational termination
• protein methylation
• gene expression
• RNA metabolic process
• mRNA metabolic process
• cellular protein metabolic process
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2107 225363 Ensembl ENSG00000120705 ENSMUSG00000024360 UniProt P62495 Q8BWY3 RefSeq (mRNA) NM_004730.3 NM_144866.3 RefSeq (protein) NP_004721.1 NP_659115.3 Location (UCSC) Chr 5:
137.84 – 137.88 Mb Chr 18:
34.9 – 34.93 Mb PubMed search


Eukaryotic translation termination factor 1 (eRF1), also known asTB3-1, is a protein that in humans is encoded by the ETF1 gene.

In eukaryotes, there is only one release factor, eRF, which recognizes all three stop codons in place of RF1, RF2, or RF3. However, the overall process of termination is similar to that of prokaryotes.

Read more about Eukaryotic Release Factors:  Function

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