There are three known estrogen related receptors:
- ERRα (ESRRA)
- ERRβ (ESRRB)
- ERRγ (ESRRG)
The ERRs are members of the orphan nuclear receptor family.
ERR's bind to estrogen response elements on DNA and modulate transcription but do not bind to endogenous estrogens.
In addition, ERR's seem to have their own response elements termed ERRE's. ERR's have been shown to play a role in energy homeostasis and cancer.
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