Types
The following is a list of the five major families of catalytic receptors:
Family | Member | Gene | Catalytic activity | Endogenous Ligands | Synthetic Ligands |
---|---|---|---|---|---|
Erb | ErbB1 (epidermal growth factor receptor) | EGFR | tyrosine kinase EC 2.7.10.1 | Epidermal growth factor, amphiregulin, betacellulin, epigen, epiregulin, HB-EGF, TGFa | GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 |
ErbB2 | ERBB2 | " | |||
ErbB3 | ERBB3 | " | NRG-1, NRG-2 | GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 | |
ErbB4 | ERBB4 | " | Betacellulin, epiregulin, HB-EGF, NRG-1, NRG-2, NRG-3, NRG-4 | GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 | |
GDNF (glial cell-derived neurotrophic factor) | GFRa1 | GFRa1 | " | GDNF > neurturin > artemin | |
GFRa2 | GFRa2 | " | Neurturin > GDNF | ||
GFRa3 | GFRa3 | " | Artemin | ||
GFRa4 | GFRa4 | " | Persephin | ||
NPR (natriuretic peptide receptor) | NPR1 | NPR1 | guanylyl cyclase EC 4.6.1.2 | Atrial natriuretic peptide | |
NPR2 | NPR2 | " | C-type natriuretic peptide | ||
NPR3 | NPR3 | " | Atrial natriuretic peptide | ||
NPR4 | NPR4 | " | Uroguanylin | ||
trk neurotrophin receptor | TrkA | NTRK1 | tyrosine kinase EC 2.7.10.1 | Nerve growth factor > NT-3 | GW441756, tyrphostin AG879 |
TrkB | NTRK2 | " | Brain-derived neurotrophic factor, NT-4/NT-5 > NT-3 | ||
TrkC | NTRK3 | " | NT-3 | ||
p75 | NGFR | " | NGF, BDNF, NT3, NT4/5 | ||
Toll-like | TLR1 | TLR1 | " | ||
TLR2 | TLR2 | " | Peptidoglycan | ||
TLR3 | TLR3 | " | polyIC, polyinosine-polycytosine | ||
TLR4 | TLR4 | " | LPS, lipopolysaccharide derived from Gram-negative bacteria | ||
TLR5 | TLR5 | " | Flagellin | ||
TLR6 | TLR6 | " | |||
TLR7 | TLR7 | " | resiquimod, imiquimod | ||
TLR8 | TLR8 | " | |||
TLR9 | TLR9 | " | CpG, DNA enriched in cytosine:guanosine pairs | ||
TLR10 | TLR10 | " |
Read more about this topic: Enzyme-linked Receptor
Famous quotes containing the word types:
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—Henry Brooks Adams (18381918)
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—Michael Blankfort. Lewis Milestone. Johnson (Reginald Gardner)