Endothelium-derived relaxing factor (EDRF) is produced and released by the endothelium to promote smooth muscle relaxation. The best-characterized is nitric oxide (NO). Some sources equate EDRF and nitric oxide.
It is released in response to a variety of chemical and physical stimuli. It causes the smooth muscle in the vessel wall to relax.
EDRF was discovered and characterized by Robert F. Furchgott, a winner of the Nobel Prize in Medicine in 1998 with his co-researchers Louis J. Ignarro and Ferid Murad.
According to Furchgott's website at SUNY Downstate Medical Center, "...we are investigating whether the endothelium-derived relaxing factor (EDRF) is simply nitric oxide or a mixture of substances".
Although there is strong evidence that nitric oxide elicits vasodilation, there is some evidence tying this effect to neuronal rather than endothelial reactions.
Famous quotes containing the words relaxing and/or factor:
“Each reaching and aspiration is an instinct with which all nature consists and cöoperates, and therefore it is not in vain. But alas! each relaxing and desperation is an instinct too. To be active, well, happy, implies courage. To be ready to fight in a duel or a battle implies desperation, or that you hold your life cheap.”
—Henry David Thoreau (1817–1862)
“In his very rejection of art Walt Whitman is an artist. He tried to produce a certain effect by certain means and he succeeded.... He stands apart, and the chief value of his work is in its prophecy, not in its performance. He has begun a prelude to larger themes. He is the herald to a new era. As a man he is the precursor of a fresh type. He is a factor in the heroic and spiritual evolution of the human being. If Poetry has passed him by, Philosophy will take note of him.”
—Oscar Wilde (1854–1900)