End Point of Clinical Trials

End Point Of Clinical Trials

An endpoint is something which is measured in a clinical trial or study. Measuring the selected endpoints is the goal of a trial. The response rate and survival are examples of the endpoints.

A clinical trial will usually define or specify a primary endpoint as a measure that will be considered success of the therapy being trialled (e.g., in justifying a marketing approval). The primary endpoint might be a statistically significant improvement in median overall survival (OS). A trial might also define one or more secondary endpoints such as median progression-free survival (PFS) that will be measured and are expected to be met. A trial might also define exploratory endpoints that are less likely to be met.