Medical and Research Achievements
Nabel has made many contributions to basic and clinical research on the pathogenesis and treatment of cardiovascular diseases. She has long championed the concept “from bench to bedside” which is reflected in her work that intertwines basic research and translation to clinical medicine. Early in her career, she made seminal discoveries regarding genetic therapies for cardiovascular disease, having developed methods for the introduction and expression of recombinant genes into blood vessels. These basic studies were instrumental in designing device therapies, in combination with genes or drugs, to treat the vascular disease restenosis. In addition, Nabel has delineated the mechanisms by which cell cycle and growth factor proteins regulate the proliferation of vascular cells in blood vessels, a process important for the development of atherosclerosis and restenosis. Her vascular biology laboratory has characterized the role of cell cycle inhibitors on vascular proliferation and inflammation, and this research has opened up new avenues for therapeutic targets in the vasculature. Nabel’s current research focuses on the molecular genetics of vascular diseases. She is conducting clinical studies to understand the contribution of genetic factors to proliferative and inflammatory diseases in blood vessels, including common diseases like atherosclerosis and the rare, premature aging in Hutchinson Gilford Progeria Syndrome. . She has contributed both to policy and basic research on embryonic stem cells
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