Eif2ak3

EIF2AK3

Identifiers Symbols EIF2AK3; PEK; PERK; WRS External IDs OMIM: 604032 MGI: 1341830 HomoloGene: 3557 ChEMBL: 6030 GeneCards: EIF2AK3 Gene EC number 2.7.11.1

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • eukaryotic translation initiation factor 2alpha kinase activity • protein binding • ATP binding • protein phosphatase binding • identical protein binding
Cellular component	• cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • integral to membrane
Biological process	• skeletal system development • ossification • chondrocyte development • translation • protein phosphorylation • activation of cysteine-type endopeptidase activity involved in apoptotic process • virus-infected cell apoptotic process • ER overload response • activation of signaling protein activity involved in unfolded protein response • endoplasmic reticulum organization • lactation • positive regulation of signal transduction • negative regulation of translation • regulation of fatty acid metabolic process • calcium-mediated signaling • insulin secretion • bone mineralization • endoplasmic reticulum unfolded protein response • endocrine pancreas development • negative regulation of myelination • negative regulation of translational initiation in response to stress • positive regulation of protein binding • SREBP signaling pathway • response to endoplasmic reticulum stress • fat cell differentiation • protein autophosphorylation • insulin-like growth factor receptor signaling pathway • protein homooligomerization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9451 13666 Ensembl ENSG00000172071 ENSMUSG00000031668 UniProt Q9NZJ5 Q9Z2B5 RefSeq (mRNA) NM_004836 NM_010121 RefSeq (protein) NP_004827 NP_034251 Location (UCSC) Chr 2:
88.86 – 88.93 Mb Chr 6:
70.84 – 70.91 Mb PubMed search

Eukaryotic translation initiation factor 2-alpha kinase 3 is an enzyme that in humans is encoded by the EIF2AK3 gene. Patients with mutations in this gene develop Wolcott-Rallison syndrome.