Dyrk1a

DYRK1A

Identifiers Symbols DYRK1A; DYRK; DYRK1; HP86; MNB; MNBH; MRD7 External IDs OMIM: 600855 MGI: 1330299 HomoloGene: 55576 ChEMBL: 2292 GeneCards: DYRK1A Gene EC number 2.7.12.1

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • protein binding • ATP binding • protein self-association • tau protein binding
Cellular component	• nucleus • nucleoplasm • nuclear speck • ribonucleoprotein complex
Biological process	• mitotic cell cycle • protein phosphorylation • nervous system development • peptidyl-threonine phosphorylation • peptidyl-tyrosine phosphorylation • negative regulation of DNA damage response, signal transduction by p53 class mediator • protein autophosphorylation • positive regulation of protein deacetylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1859 13548 Ensembl ENSG00000157540 ENSMUSG00000022897 UniProt Q13627 Q61214 RefSeq (mRNA) NM_001396 NM_001113389 RefSeq (protein) NP_001387 NP_001106860 Location (UCSC) Chr 21:
38.74 – 38.89 Mb Chr 16:
94.57 – 94.7 Mb PubMed search

Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.