DPYS

DPYS

Identifiers Symbols DPYS; DHP; DHPase External IDs OMIM: 613326 MGI: 1928679 HomoloGene: 20359 ChEMBL: 2465 GeneCards: DPYS Gene EC number 3.5.2.2

Gene Ontology
Molecular function	• uracil binding • thymine binding • dihydropyrimidinase activity • zinc ion binding • amino acid binding • metal ion binding • phosphoprotein binding
Cellular component	• cytosol
Biological process	• pyrimidine nucleobase metabolic process • pyrimidine nucleobase catabolic process • thymine catabolic process • uracil catabolic process • beta-alanine metabolic process • small molecule metabolic process • pyrimidine nucleoside catabolic process • protein homotetramerization • nucleobase-containing small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1807 64705 Ensembl ENSG00000147647 ENSMUSG00000022304 UniProt Q14117 Q9EQF5 RefSeq (mRNA) NM_001385 NM_001164466 RefSeq (protein) NP_001376 NP_001157938 Location (UCSC) Chr 8:
105.39 – 105.48 Mb Chr 15:
39.77 – 39.86 Mb PubMed search

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.