DPO may refer to:
- Dublin Philharmonic Orchestra
- "D.P.O.", a 1995 episode of The X-Files
- Digital Phosphor Oscilloscope
- Direct public offering
- Detrended price oscillator
- Dayton Philharmonic Orchestra
- Dynamic positioning operator
- Devonport Airport's IATA code
- Disable Page Out a SCSI bit
- Diplomatic Post Office: a mailing addresses for diplomatic missions of the United States. Also see: military mail.
- Discontinued post office
- Days payables outstanding
- Days post ovulation, typically used in documenting the start of pregnancy or the onset of menstruation
- DPO, Display Power Optimizer technology from QuickLogic
In science:
- 2,5-Diphenyloxazole, an organic scintillator
In computer science:
- Double pushout graph rewriting