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- Sam Doyle (1908–1985), American folk artist
- Slow Joe Doyle (1881–1947), Major League Baseball player
- Simon Doyle (born 1966), former Australian middle distance runner
- Stephen Doyle (footballer) (born 1981), South Australian Australian rules footballer
- Stephen Doyle (hurler), Irish hurler
- Steven Doyle, chess tournament organizer
- Steve Doyle, Welsh footballer
- Steve Doyle (Wisconsin politician), American politician
- Susannah Doyle (born 1966), English actress and film director
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