Dopamine Receptor D1

Dopamine Receptor D1

Identifiers Symbols DRD1; DADR; DRD1A External IDs OMIM: 126449 MGI: 99578 HomoloGene: 30992 IUPHAR: D₁ ChEMBL: 2056 GeneCards: DRD1 Gene

Gene Ontology
Molecular function	• dopamine neurotransmitter receptor activity, coupled via Gs • dopamine neurotransmitter receptor activity • protein binding • drug binding • dopamine binding
Cellular component	• nucleus • endoplasmic reticulum membrane • plasma membrane • integral to plasma membrane • caveola • axon • neuronal cell body • dendritic spine
Biological process	• temperature homeostasis • conditioned taste aversion • behavioral fear response • synaptic transmission, dopaminergic • response to amphetamine • negative regulation of protein kinase activity • protein import into nucleus • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-activating G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • adenylate cyclase-activating dopamine receptor signaling pathway • synapse assembly • memory • mating behavior • grooming behavior • adult walking behavior • visual learning • astrocyte development • dopamine transport • transmission of nerve impulse • regulation of action potential in neuron • calcium-mediated signaling • dentate gyrus development • striatum development • cerebral cortex GABAergic interneuron migration • positive regulation of cell migration • negative regulation of cell migration • peristalsis • positive regulation of cAMP biosynthetic process • phosphatidylinositol catabolic process • cellular response to insulin stimulus • operant conditioning • regulation of dopamine metabolic process • negative regulation of circadian sleep/wake cycle, sleep • dopamine metabolic process • response to drug • eating behavior • positive regulation of potassium ion transport • glucose import • sensitization • behavioral response to cocaine • regulation of long-term neuronal synaptic plasticity • positive regulation of release of sequestered calcium ion into cytosol • elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • regulation of dopamine uptake involved in synaptic transmission • positive regulation of synaptic transmission, glutamatergic • prepulse inhibition • phospholipase C-activating dopamine receptor signaling pathway • long-term synaptic potentiation • long term synaptic depression • cellular response to catecholamine stimulus
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1812 13488 Ensembl ENSG00000184845 ENSMUSG00000021478 UniProt P21728 Q61616 RefSeq (mRNA) NM_000794 NM_010076 RefSeq (protein) NP_000785 NP_034206 Location (UCSC) Chr 5:
174.87 – 174.87 Mb Chr 13:
54.05 – 54.06 Mb PubMed search

Dopamine receptor D₁, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.