Dock180 - Signalling Downstream of Dock180

Signalling Downstream of Dock180

Dock180 is a Rac-specific GEF and so is responsible for a subset of Rac-specific signalling events. These include cell migration and phagocytosis of apoptotic cells in C. elegans, neurite outgrowth in PC12 cells and myoblast fusion in the Zebrafish embryo. More recently the DHR1 domain of Dock180 was shown to bind SNX5 (a sorting nexin) and this interaction promoted retrograde transport of the cation-independent mannose 6-phosphate receptor to the Trans-Golgi Network in a Rac-independent manner. Increased expression of Dock180 and Elmo has been reported to contribute to glioma invasion.